RESUMO
Forty two children with end stage renal failure and hypertension on chronic haemodialysis have been treated with captopril for from 18 to 78 months. Satisfactory control has been obtained in doses of 0.3 to 3.0 mg/kg given every 24 or 48 hours. Tolerance was good. The results of the present study suggest that captopril is a suitable drug for long-term use in paediatric patients.
Assuntos
Captopril/administração & dosagem , Hipertensão/tratamento farmacológico , Falência Renal Crônica/complicações , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Hipertensão/complicações , Lactente , MasculinoRESUMO
Captopril was given to 42 hypertensive patients aged 1 to 17 years who were treated by regular haemodialysis because of terminal renal failure. Initially all patients were on antihypertensive treatment without sufficient control of blood pressure. Under captopril all patients presented a significant decrease of both systolic and diastolic blood pressures. The mean decrease of systolic blood pressure was from 162 to 114 and that of diastolic blood pressure from 106 to 86 mmHg. Plasma renin activity rose significantly in all cases whereas plasma aldosterone dropped and reached normal levels for age. The maximum effective dosage was 3 mg/kg/day. Total duration of treatment with captopril ranged from 1 1/2 to 6 1/12 (mean 3 2/12) years. At last observation the dosage of captopril varied between 0.3 and 3 mg/kg/day.
